miR-29 suppression of osteonectin in osteoblasts: Regulation during differentiation and by canonical Wnt signaling
نویسندگان
چکیده
منابع مشابه
Canonical Wnt signaling activates miR-34 expression during osteoblastic differentiation.
The canonical Wnt signaling pathway is crucial for the regulation of bone mass in humans and for the development of osteoblasts. MicroRNAs (miRs) represent a class of non‑coding RNAs, ~22 nucleotides in length, that regulate gene expression by targeting mRNAs for cleavage or translational repression. Several previous studies have demonstrated the involvement of miRNAs in modulating gene express...
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Inactivation of Lrp5, a gene encoding a likely Wnt co-receptor, results in low bone mass (osteopenia) by decreasing bone formation, suggesting that Wnt signaling in osteoblasts regulates bone formation. Here we show that Tcf1 and Tcf4 are expressed in osteoblasts during development and after birth; stabilization of beta-catenin, an essential component of canonical Wnt signaling, in differentiat...
متن کاملEpigenetic regulation enables trans-differentiation Epigenetic modifications and canonical WNT signaling enable trans-differentiation of non-osteogenic cells into osteoblasts
Mesenchymal cells alter and retain their phenotype during skeletal development through activation or suppression of signaling pathways. For example, we have shown that Wnt3a only stimulates osteoblast differentiation in cells with intrinsic osteogenic potential (e.g., MC3T3-E1 preosteoblasts) and not in fat cell precursors or fibroblasts (respectively, 3T3-L1 preadipocytes or NIH3T3 fibroblasts...
متن کاملmiR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop.
Differentiation of human mesenchymal stem cells into osteoblasts is controlled by extracellular cues. Canonical Wnt signaling is particularly important for maintenance of bone mass in humans. Post-transcriptional regulation of gene expression, mediated by microRNAs, plays an essential role in the control of osteoblast differentiation. Here, we find that miR-29a is necessary for human osteoblast...
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Since the discovery of first Wnt gene (Wnt-1) in 1982, numerous investigations have focused on the roles of different Wnt proteins in regulation of cellular proliferation, differentiation and apoptosis in a cell-specific and contextual manner (Rao & Kuhl, 2011). Wnts mainly activate intracellular biological processes through one canonical pathway and two wellcharacterized non-canonical pathways...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2009
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.22243